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Question:
I have seen advertisements for a supplement containing calcium D-glucarate to prevent breast cancer. How does this product work?
Answer:
Calcium D-glucarate is a natural substance used to inhibit an enzyme in certain bacteria that reside in the gut - beta-glucuronidase. One of the key ways in which the body gets rid of hormones like estrogen is via attaching glucuronic acid to the hormone in the liver and then excreting this complex in the bile. Beta-glucuronidase is a bacterial enzyme that uncouples (breaks) the bond between excreted hormone and glucuronic acid. When beta-glucuronidase breaks the bond, the freed hormone is available to be reabsorbed back into the body instead of being excreted. An elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers like breast and prostate as well as colon cancer.
By taking calcium D-glucarate, the activity of beta-glucuronidase is inhibited. As a result the body is better able to get rid of excess hormones like estrogen. Since most breast cancers are dependent upon estrogen, researchers at M.D. Anderson Cancer Center, Memorial Sloan-Kettering Cancer Center, and other major cancer centers began conducting research with calcium D-glucarate in the prevention and treatment of breast cancer. The preliminary results are quite encouraging. The recommended daily dosage for prevention is 200 to 400 mg. Higher dosages (i.e., 400 to 1,200 mg) may be necessary for individuals with existing breast cancer.
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